Antibody Development Job Opportunity

26 February 2020

The LeBeau research lab at the University of Minnesota in the Dept of Pharmacology is looking to hire a few lab technicians this spring/early summer for full-time employment. The ideal candidate would be a graduating senior looking to do research for 1-2 years before going on to graduate or professional school.

For more information about the lab click here. For more information about the department click here.

Required qualifications: BS degree in the Biological Sciences, preferably biochemistry, molecular biology, or related field; strong communication skills; experience in team dynamics; strong problem solving skills. Preferred qualifications: strong understanding of molecular biology and immunology; wet lab experience beyond laboratory classes.

The LeBeau lab is seeking a scientist to aid primarily with antibody development and characterization. Additional tasks will involve in vitro assays such as ELISA, Molecular Cloning, Protein Expression, Flow Cytometry, Tissue Culture, and Fast Protein Liquid Chromatography. Candidate should be willing to learn animal work for in vivo experiments.

75% of the job will be research. Screening of antibody phage display libraries against recombinant proteins and clinical tissue in order to identify novel antibody/antigen combinations associated with drug resistant prostate cancer. Candidate will make chimeric antigen receptor constructs for the development of targeted cell-based therapeutics for the treatment of prostate cancer.

25% of the job will be laboratory support. Candidate will assist current lab manager and other lab staff with general upkeep and maintenance of the laboratory. Maintain lab equipment, write and update standard operating procedures, purchase supplies and equipment, prepare common reagents.

The LeBeau lab focuses on the pre-clinical development of novel therapeutic and imaging agents for metastatic prostate cancer. The laboratory specializes in antibody phage display–a technique that allows for rapid identification of antibody fragments against cancer-associated antigens. When coupled to radioisotopes, the antibodies are employed as positron-emission tomography (PET) nuclear imaging or radioimmunotherapy agents. Additionally, the lab is developing cell-based therapeutics for prostate cancer by engineering chimeric antigen receptor (CAR) Natural Killer (NK) cells for adoptive cellular immunotherapy. Click here to learn more about the lab’s research.

If interested, please send your resume and cover letter to alebeau@umn.edu