Chemistry Department Seminar: Student Comps Presentation
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Will Feng, Gavin Hazen, Helen Jin-Lee, Ethan Li, Tommy Lisko, Michaela Polley, Tony Qiang, Alex Rowell, Allison Teichman - Odom group presentation
"A Gold Star Approach: Using Gold Nanostars as a Drug Delivery Vehicle for Cancer Treatment"
How can gold nanostars serve as effective delivery vehicles for targeted cancer therapies? Dr. Teri Odom and her research group at Northwestern University are developing biocompatible gold nanoconstructs consisting of gold nanostars (AuNS) loaded with an anticancer drug (DNA aptamer AS1411) to selectively target cancer cells. AuNS can be synthesized using a seedless, scalable method that allows for controlled tunability of nanostar size, shape, and optical properties. AS1411 binds specifically and with high affinity to nucleolin (NCL), a receptor that is highly expressed in cancer cells. The Odom group has improved the stability of AS1411 in physiological conditions by grafting the aptamer onto the surface of AuNS by taking advantage of the easy functionalization of the gold surface. The gold nanoconstructs deliver a high, local concentration of AS1411 to cancer cells, resulting in cell death.
*This seminar counts towards the chemistry major seminar attendance requirement for all majors not doing comps this year.
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Meeting ID: 919 7269 3602
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