Sep 23

Chemistry Department Seminar: Jen Heemstra, Emory University

Fri, September 23, 2022 • 3:30pm - 4:30pm (1h) • Anderson 329

A chemical biology toolbox for probing A-to-I RNA editing

Official/Unofficial Story

 

RNA undergoes extensive modification through enzymatic post-transcriptional editing events. Adenosine-to-inosine (A-to-I) editing is one of the most widespread and impactful of these modifications and is catalyzed by adenosine deaminases acting on RNA (ADARs). Resulting inosines base pair with cytosine, essentially re-coding adenosine sites to guanine. Editing is essential for a number of processes including embryogenesis, neurological function, and innate cellular immunity. Dysfunctional editing is also linked to auto-immune diseases, neurological disorders, and several types of cancer. Despite this importance, numerous challenges remain for studying A-to-I editing, and our overall understanding of the locations and frequency of inosine sites remains limited. To address this challenge, we have repurposed EndoV from an RNA-cleaving enzyme into an RNA-binding protein and demonstrated its use for mapping of A-to-I editing sites and global profiling of RNA inosine content in cells and tissue samples.

*This seminar counts towards the chemistry major seminar attendance requirement.

Event Contact: Tami Little

Event Summary

Chemistry Department Seminar: Jen Heemstra, Emory University
  • When
    • Friday,¬†September¬†23,¬†2022
    • 3:30pm - 4:30pm (1h)
  • Where
    • Anderson 329
  • Event Contact
  • Intended For: General Public, Students, Faculty, Staff
  • Categories: Lecture/Panel

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