Chemistry Department Seminar: André Isaacs, College of the Holy Cross
"A Click Chemistry Approach to Nitrogen Heterocycles"
Our research interests are centered on a very reliable organic reaction - the copper-catalyzed cycloaddition of sulfonyl azides and terminal alkynes (CuAAC). Differential fragmentation of the resulting 1,2,3-triazole generates ketenimines and rhodium carbenoids which readily engage with a variety of nucleophiles to gain access to heterocycles of interest to the synthetic community. Herein, we demonstrate the utility of ketenimines in the synthesis of N-Heterocycles such as indolizines, dihydroisoquinolines and beta-lactams.
*This seminar counts towards the chemistry major seminar attendance requirement.