Apr 25
Chemistry Department Seminar: Bobby Arora (NYU)
Professor of Chemistry, New York University
"Protein Domain Mimics as Rationally Designed Modulators of Biomolecular Function"
We are pursuing a systematic approach to develop synthetic inhibitors of protein-protein and protein-RNA interactions. Proteins often utilize small folded domains for recognition of other biomolecules. The basic hypothesis guiding our research is that by mimicking these domains we can modulate the function of a particular protein with metabolically stable synthetic molecules. This presentation will discuss covalent constraints to stabilize protein domain mimics (PDMs) in isolated sequences, and the use of the PDMs to rationally design inhibitors of protein-protein and protein-nucleic acid interactions.
*This seminar counts towards the chemistry major seminar attendance requirement.