Oct 25
Chemistry Department Seminar: Matt Bush '03, University of Washington
Associate Professor, Department of Chemistry, University of Washington, Seattle
"New Mass Spectrometry Based Technologies for Biophysics and Structural Biology"
Native-like ions are generated using electrospray ionization of proteins, nucleic acids, lipids, and other biological molecules in aqueous solutions. These gas-phase ions can retain noncovalent interactions that were present in the original solution, and consequently, native ion mobility (IM) mass spectrometry (MS) has great potential for answering many questions in biophysics and structural biology that have eluded condensed-phased strategies. I will report new technologies that my lab developed to probe the structures and structural evolution of proteins and their complexes. I will then discuss how my lab has applied these technologies to answer questions related to regulating protein degradation.
*This seminar counts toward the chemistry major seminar attendance requirement.