Mar 3
Biology Seminar: Cameron McDonald-Hyman '09, "Modulating T-cell Metabolism to Enhance Cellular Therapies for Blood Cancers and Inflammatory Diseases
Mon, March 3, 2025
• 3:30pm
- 4:30pm (1h) • Olin 141
The metabolic activity of immune cells is directly linked to their function. T-lymphocytes (T-cells) use a combination of glycolysis and mitochondrial metabolism (oxidative phosphorylation) to generate ATP. However, the local availability of nutrients (glucose, fatty acids, lactic acid, amino acids), determines the pathways T-cells utilize to make ATP, which results in downstream changes to the functional activity of T-cells. By inhibiting or augmenting specific metabolic pathways, we can take advantage of inherent T-cell wiring to augment their functionality and enhance the efficacy of T-cell therapies for patients.
Event Contact: Peter Stone