The Chen lab aims to generate novel therapies to treat cancer and autoimmune diseases
based on our basic science understanding about RNA function and regulation. We investigate the mechanisms and regulation of circular RNAs (circRNAs), a newly identified class of ubiquitous RNAs in essentially all eukaryotes and some viruses. Thus far, circRNAs have been found to function as miRNA sponges, regulate transcription, and act as templates for translation. However, there are still many unanswered questions: What other functions do circRNAs possess? How are circRNAs degraded? What are their interacting proteins? Specifically, we aim to understand how different layers of regulation including RNA modifications and cellular localization affect RNA function to enable new insights into both normal function and how dysregulation leads to disease. The Chen Laboratory applies molecular, cellular, and chemical biology techniques coupled with next-generation sequencing to address these questions.
For more information, visit gracechenlab.org. Interested applicants please send a brief statement of interest and curriculum vitae with contact information for three references to the PI Dr. Grace Chen at email@example.com.
Training as a Postgraduate Associate, the candidate will perform basic science and/or translational research related to ongoing projects including molecular cloning, culture of mouse and human cell lines, CRISPR-based screening, and biochemical techniques. Direct mentorship from the PI, and opportunities to pursue independent research will be provided.
Mentoring the post-graduate researcher will work closely with members of the Chen lab and Professor Chen to gain experience in the design, execution, and analysis of experiments. In addition, the candidate will be given career development opportunities (e.g. scientific writing and public speaking skills) that are individually tailored to her/his long-term career goals. The ultimate goal is to create an experience that is rewarding and engaging for the successful applicant and to foster scientific, professional, and/or educational advancement. This position is an excellent fit for researchers interested in gaining research experience and skills before pursuing a Ph.D. in molecular biology or a related field.
The ideal candidate has completed a Bachelor’s degree in the Biological or Chemical Sciences with significant laboratory coursework. Prior research experience, particularly in mammalian cell culture, molecular biology, or biochemistry, is highly desirable.